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Study limitations Although pomegranate extract effects on TMAO production were observed in female participants of premenopausal age and male participants, this remains a proof-of-concept study with a small population and smaller subgroups, including only three female participants in the Older (postmenopausal age) group and three in the Younger (premenopausal age) group

49 ) to increase NAD + recycling and promote increases in mitochondrial-driven respiration, as shown by Seahorse XF analysis (Fig

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