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The WGS data revealed the integration of a marker resistance gene, the deletion of the endogenous rib operon, and the presence of four putative recombinant pBR322 and pUC-based plasmids harboring additional rib operons

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On-Therapy Monitoring Schedule Weeks 4 and 8: IGF-1, ALT, AST, albumin, fasting glucose, body weight Week 12: Full CMP, IGF-1, HbA1c, PT/INR, Child-Pugh re-score Every 3 months thereafter: IGF-1, liver panel, albumin Target IGF-1 in the mid-normal range for age and sex

Topiramate's exact mechanism for weight loss is not fully understood but may involve affecting neurotransmitters and curbing cravings

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