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Drug Metab Rev

Accumulation of these compounds causes tissue damage through oxidative damage of cellular structures, that is, proteins, membrane lipids and nucleic acids (Reference Halliwell and Gutteridge44)

PMID 20712757

Lipid Modulation GLP-1RAs exert favourable effects on lipid profiles, primarily reducing triglycerides and, to a lesser extent, LDL cholesterol.12 These effects could be secondary to reduced hepatic lipogenesis, increased fatty acid oxidation and modulation of lipoprotein metabolism.13 Improved Energy Expenditure GLP-1RAs may increase energy expenditure

As for phase II metabolism, the role of UGT in statin metabolism and SIM should be further explored