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Hewitt SC, Wu SP, Wang T, Young SL, Spencer TE, DeMayo FJ (2022) Progesterone Signal Endometrial Epithel Organoids Cells 11

Color change, either loss of the blue tint or darkening, indicates copper oxidation affecting the peptide

Metab Brain Dis 41 , 24 (2026)

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However, critical barriers hinder their clinical translation: (1) regulatory and scalability challenges, such as standardizing sterilization/long-term stability for liposomes/SLNs, require rigorous evaluation of immune responses (e.g., PEGylated liposomal uricase) and cost-effectiveness for advanced systems (biomimetic nanoliposomes and ethosomal gels)