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10.1371/journal.pone.0215565 4 AppleJ.DerSarkissianM.ShahA.ChangR.ChenY.HeX.et al (2023)
Additionally, tirzepatide was designed to bind to the GIPR with an affinity 5-fold stronger than that for the GLP1R, resulting in greater potency and selectivity in engaging the GIPR over the GLP1R
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