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Dasari A, Yu G, Kopetz S , Puhalla SL, Lucas PC, Halil Sahin IH, Deming DA, Philip PA, Hong TS, Rojas-Khalil Y, Loree JM, Wolmark N, Yothers G, George TJ, Lieu CH

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LPS activates macrophages through TLR 4, prompting the release of inflammatory factors such as IL-1 and TNF- , which drive Th 1 differentiation and promote IFN- secretion, further magnifying local inflammation in the thyroid gland (Zhang et al., 2023)