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175 CRTCs have also been suggested to be involved in ACTH-induced transcription of StAR (Steroidogenic Acute Regulatory) protein, where ACTH mediates the recruitment of CRTC2 and CRTC3 to the StAR promoter leading to increased levels of Star heteronuclear RNA, 176 indicating that these co-activators modulate context-specific activation of diverse genes

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