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A: Estrogen-based HRT prescribing has more than doubled since 2018, driven by increased perimenopause recognition, cultural destigmatization, updated clinical guidelines, and the FDAs removal of boxed warnings on HRT products

* Influencing factors: Drug solubility, vesicle size, lipid concentration, and preparation procedures

As more people discover their advantages, GLP-1s are being prescribed earlier in the treatment journey, often displacing longstanding first-line therapies like metformin

Overall Distribution 9.2.2

Furthermore, previous studies have shown that a gradual decrease in ECM1 expression is associated with the progression of hepatic fibrosis within the liver [11]