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In a phase II trial, adults with a BMI of 30 or 27 kg/m with comorbidities were randomized to receive efpeglenatide at doses of 4 mg weekly, 6 mg weekly, 6 mg biweekly, or 8 mg biweekly, or a placebo, all combined with a hypocaloric diet [17]

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Id be very cautious about products like that, says Raj Dasgupta, MD , associate professor of clinical medicine at the University of California, Riverside School of Medicine

People lost up to 24% of their body weight over 48 weeks in Phase 2 trials published in the New England Journal of Medicine in 2023