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A deficiency in vitamin B12 may be found in persons with a diet limited in animal foods (such as vegans), or those with medical ailments affecting vitamin absorption

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For researchers focused specifically on weight management outcomes, the full escalation to 12mg provides the most robust data, though the 8mg dose produced 22.8% weight loss, only 1.4 percentage points less

Patients were randomized (1:1:1:1) by using an interactive web-response system to once a week treatment with either semaglutide 0.5 mg, dulaglutide 0.75 mg, semaglutide 1.0 mg, or dulaglutide 1.5 mg subcutaneously