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The study employed a dose-escalation protocol to mitigate gastrointestinal side effects: Weeks 04: 2 mg once weekly (for groups escalating to 4 mg, 8 mg, or 12 mg) Weeks 58: 4 mg once weekly (for groups escalating to 8 mg or 12 mg) Weeks 912: 8 mg once weekly (for the 12 mg group only) Weeks 1348: Maintenance dose (4 mg, 8 mg, or 12 mg depending on group assignment) This gradual escalation reduced the incidence and severity of nausea compared to immediate initiation at higher doses

Several factors that can affect coverage include someones health history, specific insurance plan, and what its prescribed for