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doi: 10.1517/17460441.2015.1044966 3 Perez-CamposEMayoralL-CAndradeGMayoralE-CHuertaTCansecoSet al
The main adverse reactions were gastrointestinal side effects, including nausea, diarrhea, and vomiting
This article breaks down that paradox, explains why discomfort is such a powerful biological signal, and shows how intensity shapes everything from lactate metabolism to brain chemistry to long-term resilience
One placebo-controlled trial, called ATTAIN-MAINTAIN, followed adults who had previously completed the SURMOUNT-5 obesity trial, a randomized controlled study evaluating whether tirzepatide, the active ingredient in Zepbound, led to greater body weight reduction versus semaglutide in adults with obesity
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