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Reducing alcohol intake supports GSH and prevents ROS damage 49

Feelings of sleeplessness or overstimulation may occur, discontinue use if feelings persist or worsen

The article says naltrexone blocks opioid receptors in the hypothalamus, removing inhibition of pro-opiomelanocortin neurons that regulate satiety, while bupropion is a norepinephrine-dopamine reuptake inhibitor that increases alertness and reduces appetite by raising dopamine and norepinephrine in the brain's appetite-control centres