In animal models of acute lung injury induced by lipopolysaccharide (LPS), GHK-Cu treatment reduced reactive oxygen species (ROS) production and increased superoxide dismutase (SOD) activity while decreasing TNF- and IL-6 production
also declares personal honoraria/lecture fees from AstraZeneca, Boehringer Ingelheim, Medscape, Napp, Menarini, Novo Nordisk and Rhythm
LiSCaoJShiZChenJZhangZHughesCet al
Fungicidal effect (kills fungi directly)
Activated JNK translocates to mitochondria and phosphorylates anti-apoptotic Bcl-2 family members (e.g., Bcl-2 phosphorylation at serine residues such as Ser70) leading to functional inactivation of Bcl-2/Bcl-xL, and promotes pro-apoptotic conformational changes and mitochondrial translocation of Bax (55, 56)