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Excess body fat, especially visceral fat, lowers testosterone by increasing estrogen and disrupting endocrine balance

Melatonin drives glutathione accumulation in ILC2s Whilst we noted that melatonin suppressed glycolysis in ILC2s ( Figure 5E ), we also found that glucose uptake remained unchanged ( Figure 5K )

This allows toxic microbial metabolites and other harmful substances to enter systemic circulation, activating the immune system and promoting the release of pro-inflammatory cytokines

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