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*Correspondence: Kazuki Saito, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8675, Japan e-mail: [email protected] This article was submitted to Plant Physiology, a section of the journal Frontiers in Plant Science

Materials and methods Docking and system Preparation The X-ray crystal structure and sequence of tyrosinase bound with tropolone and copper (PDBID: 2Y9X) were obtained from the RCSB Protein Data Bank ( 49

49,50 Also, toys and other childrens products may contain lead or be painted with lead-based paint