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Four JAKs (JAK1, JAK2, JAK3, and TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, and STAT6) were reported to be present (143)

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The full scope at Ascend includes: Obesity and overweight with comorbidities - full workup, GLP-1 candidacy assessment, lifestyle integration Type 2 diabetes with weight management goals - GLP-1 medications often address both indications simultaneously Hypertension tied to weight - coordinated medication review and lifestyle work Dyslipidemia and metabolic syndrome - lipids often improve markedly with weight loss Prediabetes - HbA1c 5.7-6.4% range, where intervention can prevent progression Fatty liver disease (MASLD) - weight loss is the primary intervention