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Forecasting analysis predicts that both incidence and mortality will continue to rise over the next three decades, reaching their peaks by 2049, particularly in older age group [41]

According to the different connection modes of the C3, flavonoids can be divided into several sub-types, including flavones, flavanones, flavonols, flavanols, isoflavones, chalcones, aurones, and anthocyanidins (Huynh et al., 2014

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In periods of nutritional deficiency, stress, increased reactive oxygen species (ROS), toxicity, mitochondrial dysfunction, cellular proliferation, Phase 2 detoxification, etc

Thanks also to Christian for the MD simulations, and to Amedeo, Jason, Winston, and Jorge for their valuable advice, support, and help along the way