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During freeze-drying, the peptides are gently frozen and placed under low pressure so the water turns straight from ice into vapor

[DOI] [PubMed] [Google Scholar] 120.Fetissov S.O., Harro J., Jaanisk M., Jrv A., Podar I., Allik J., Nilsson I., Sakthivel P., Lefvert A.K., Hkfelt T

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There may be a brief pinch or mild pressure