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Is there a role for glucagon-like peptide-1 receptor agonists

Because the medication significantly amplifies satiety signals, eating past the first indication of fullness can quickly produce significant discomfort

For longer-acting preparations, there is no clinical need to link injections to meals, though some patients prefer to establish a routine that includes a regular mealtime as a reminder

There are a myriad of medical benefits derived from these medications, including improvements in chronic medical conditions such as hypertension, hyperlipidemia, and sleep apnea, says Lauren Turchin-Orent, MD

Clinical trials for GLP-1 agonists have reported musculoskeletal side effects such as back pain and muscle pain in a small percentage of participants, but joint pain specifically has not emerged as a consistent or significant adverse event across the class