5.1.2 Topiramate as an antioxidant Topiramate exhibits complex and context-dependent effects on oxidative stress
Most notably, Nos-3 expression was increased in a dose-dependent manner (Fig
Population studies have demonstrated that elevated levels of LDL cholesterol and apolipoprotein B (apoB) 100, the main structural protein of LDL, are directly associated with risk for atherosclerotic cardiovascular events (ASCVE)
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(2015), BioMed Research International 2015:648108, PubMed 26236730 Statistiken aus der Forschungsliteratur Entdeckt von Loren Pickart im menschlichen Blutplasma im Jahr 1973 als Faktor, der die Langlebigkeit kultivierter Leberzellen erhht Kleinstes Peptid mit pharmakologischer Aktivitt: 3 Aminosuren (Gly-His-Lys) + ein Cu -Ion Molekulargewicht: 402 Da INCI-Name in der EU-Kosmetik: Copper Tripeptide-1 (registriert in der CosIng-Datenbank der EU-Kommission) Modulation der Genexpression: 4 000 menschliche Gene (Connectivity Map dataset, Pickart 2015) Der Plasmaspiegel sinkt bei gesunden Menschen von ~200 ng/mL im Alter von 20 Jahren auf ~80 ng/mL im Alter von 60 Jahren (62 % Rckgang) Am intensivsten untersuchte Bioaktivitt: Fibroblasten-Proliferation , Kollagen-I/III-Synthese , antioxidative Aktivitt (SOD upregulation) Referenzquellen (PubMed) Pickart L., Vasquez-Soltero JM., Margolina A
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