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The functional status of p53, in combination with other molecular markers, such as oestrogen and progesterone receptors, B-cell lymphoma 2 (Bcl-2), BCL2-associated X (Bax), and human epidermal growth factor receptor 2 (HER-2), provides insight into tumour proliferative capacity and replicative potential, making it a critical mechanistic hub in breast cancer biology (4345)