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In the matched expanded populations, the mean age ranged from 59.2 to 69.2 years, 50.455.8% were female and the mean body mass index (BMI) ranged from 34.5 to 38.7 kg m 2

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Hypoglycemia awareness Tight glycemic control is a risk factor for impaired glucose counter-regulation and hypoglycemia unawareness lower levels of HbA1c result in a resetting of thresholds for the counter-regulatory and symptomatic responses to hypoglycemia at lower glucose concentrations