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By activating these receptors in the brains satiety centers (like the area postrema), it promotes feelings of fullness, reduces food intake, and helps stabilize post-meal blood sugar spikes, making it a promising candidate for weight management, particularly in combination with the GLP-1 receptor agonist semaglutide (marketed as CagriSema)

It is temporary

Zi-Di Xu, Zhang W, Sang Y-M, et al

9 So through multiple mechanisms, SIBO can indirectly result in excess histamine in the gut

At that time, you should then discuss with your doctor if remaining on a maintenance dose would be beneficial or even trying a no-drug period would be warranted