These FDA-approved medications include semaglutide (Wegovy), liraglutide (Saxenda), and tirzepatide (Zepbound), which work through multiple physiological mechanisms to promote weight reduction
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Either way, the practical implication is similar, and it is arguably the most consequential consideration for anyone planning future work: on the brain-access hypothesis, novel dual GLP-1/GIP agonists engineered specifically for brain entry would be more rational next candidates to test than repurposed diabetes drugs chosen for market availability
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