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This means they dont undergo the same comprehensive checks and evaluations when it comes to proving their effectiveness

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Diagnosis typically involves pelvic examination and imaging, most commonly transvaginal ultrasound

This opens a possibility to use limited proteolysis as a tool for conformational analysis of proteins, where a very significant role was played by the laboratory of Angelo Fontana, who emphasized that the proteolytic probes can pinpoint the sites of local unfolding in a protein chain (Fontana et al., 1986