The antioxidant properties of several natural compounds related to the activation of NRF-2 have been investigated [43], such as curcumin [97], KIOM-4, Resveratrol, Zinc, Berberine, L-arginine, oleanolic acid, vitamin D, among others, in animal cell cultures, with disagreeing results, mainly focused on the decrease of OS or the increase of elements of antioxidant response through NRF-2 [43]
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Catalpol enhances the expression of brain-derived neurotrophic factor (BDNF) by upregulating the phosphorylation of cAMP response element-binding protein (CREB), improving the survival of -amyloid (A)-damaged SH-SY5Y neuroblastoma cells, and providing a theoretical basis for its neuroprotective effects in Alzheimers disease ( In summary, catalpol has demonstrated robust in vitro and in vivo neuroprotective activity against various neurological conditions, including those induced by rotenone, OGD/reoxygenation in SH-SY5Y cells, lead in PC12 cells, LPS in BV-2 cells, traumatic brain injury, spinal cord injury, cognitive impairment, and Alzheimers disease
