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Important mediators that draw immune cells to the skin and intensify the autoimmune assault on melanocytes include CXCL10 and CXCL9

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Unlike laminar shear stress, this type of shear stress is pro-atherogenic, pro-inflammatory and contributes to ECD, making it a key factor in the development of atherosclerosis and other cardiovascular diseases [203]

Aldosterone is also a key component of the renin-angiotensin-aldosterone system (RAAS) in which specialized cells of the kidneys secrete the enzyme renin in response to low blood volume or low blood pressure

Another characteristic feature of PD pathology is the presence of eosinophilic inclusions (530 in diameter) in the soma of the surviving neurons (Lewy bodies or LBs) which are visible in routine histopathological staining (Hartmann, 2004