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Nausea, vomiting, diarrhoea, decreased appetite, constipation, and abdominal discomfort are most common, usually during the dose-escalation period, and typically improve with time

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It is a cofactor in the metabolism of fatty acids and its derivative acetyl-L-carnitine helps regulate carbohydrate, protein, and fatty acid metabolism and cellular energy production

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Studies show that GI side effects in tirzepatide trials were predominantly mild to moderate and concentrated during the dose escalation period