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Biochemical and omics biomarkers in cognition Classical CSF and plasma biomarkers A40 / A42 (important ratio in amyloid pathology) Total tau / p-tau181 / p-tau217 (tauopathic markers) Neurofilament light (NfL) : axonal degeneration marker GFAP : astrocytic activation BDNF and pro-BDNF : neurotrophic activity IL-6, TNF, IL-1 : neuroinflammation Transcriptomics and epigenomics Hippocampal RNA-seq after chronic administration of Semax or Selank often reveals a neurotrophic activation signature (BDNF, NT3, NGF, NR4A1-3) coupled with anti-inflammatory modulation (NF-B targets down)
NMN and NR Have Different Cell Transport Mechanisms NMN and NR Have Different Cell Transport Mechanisms To make NAD+, the cell ultimately needs to get its hands on NMN
IGFBP-1 production from the liver is significantly elevated during insulinopenia while serum levels of bioactive IGF-1 is increased by insulin
Among adults with diabetes, CVD death rates are 2-4 higher than the rates for adults without diabetes [2]
The human milk globules have an even more unique tri-layer structure
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