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It is also notable that significant reduction in unstable angina and unplanned revascularization with the use of GLP-1RA was observed in the secondary preventative cohort, potentially translating to clinical impact in individuals with prior ASCVD events

The bidirectional relationship be-tween these conditions is well established, as MASLD increases the risk of T2DM onset and progression, while T2DM exacerbates MASLD pathogenesis

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Both approaches are safest when aligned with individual health status

The bulk of current legal action is focused on semaglutide-based drugs, especially those used off-label or for weight loss