We report that in obese mice, GLP-1 medicines predominantly reduce body fat alongside a small but significant decrease in LBM
Some are just starting a GLP-1 and want to be proactive
However, the study design did not allow for the assessment of the effects of semaglutide on bone metabolism, independent of weight loss, as the control group did not experience comparable weight reduction
[20] [21] Seek urgent medical advice if you are already taking a GLP-1 medication and experience: Severe, persistent abdominal pain (possible pancreatitis) A new lump in your neck or changes in your voice Symptoms of severe hypoglycaemia (if taking other diabetes medications) Signs of thyroid dysfunction despite stable levothyroxine therapy Persistent vomiting leading to dehydration or inability to take oral medications Severe right upper abdominal pain, fever or jaundice (possible gallbladder disease) Open communication with your healthcare team ensures that treatment decisions are individualised, evidence-based, and aligned with your health priorities
Strategies such as amino acid substitution or cyclization, PEGylation, fusion of long-acting fragments (fusion with Fc, fusion with human serum albumin), and conjugation of fatty acid chains are commonly used, and several drugs have been successfully marketed