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The gut-brain axis involved in the mechanism of PND comprises multiple communication routes, including gut barrier and the blood-brain barrier (BBB), endocrine, neural pathways, the immune system and gut microbiota metabolism

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2f), with a clear increase to protease accessibility in the dephosphorylated state as judged by a more complete digestion (ie loss of intermediate-sized bands) in the dephosphorylated state

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