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The extent and intensity of physiological oral pigmentation increases with age[52, 53], concurrently with an increase in the number of oral melanocytes[15], perhaps because of the effects of potentially melanogenic stimuli such as recurrent minor functional injury, inflammatory conditions, medication, or tobacco smoke are cumulative[3]

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In contrast, Akt is a protein kinase involved in various cellular functions like glucose metabolism, apoptosis, cell growth, transcription, and cell movement

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