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Abstract Glucagon-like peptide-1 (GLP-1) was initially considered to be a hormone with a predominant role in regulating glucose metabolism by inducing insulin secretion, reducing glucagon secretion, and ameliorating insulin resistance, with the last effect being largely dependent on the induction of weight loss

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If patients are simultaneously becoming less active while on these drugs, as this study suggests, that combination may accelerate muscle loss rather than protect against it

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