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A few key players in the market are AstraZeneca

Clinical trials showed 24.2% average weight loss at 48 weeks using the 12mg dose

In the pool of five placebo-controlled clinical trials in adults, adverse reactions related to volume depletion (e.g., blood pressure (ambulatory) decreased, blood pressure systolic decreased, dehydration, hypotension, hypovolemia, orthostatic hypotension, and syncope) were reported by 0.3%, 0.5%, and 0.3% of patients treated with placebo, empagliflozin 10 mg, and empagliflozin 25 mg, respectively

Lancet 393 , 20512058 (2019)

In a study by Chen and Hong, it was investigated that IGF-1 and IGF-1R were found to be correlated with AGEs in CRC patients with T2DM