Importantly, the ferroptosis suppressor protein 1 (FSP1)-coenzyme Q10 (CoQ10)-nicotinamide adenine dinucleotide (Phosphate) [NAD(P)H] and tetrahydrobiopterin (BH4)-dihydrofolate reductase (DHFR) pathways, though functioning independently, complement each other and, alongside GPX4 and glutathione, play crucial roles in preventing phospholipid peroxidation and, consequently, ferroptosis [114,115,116]
For example, microspherocytosis in autoimmune hemolytic anemia, macro-ovalocytes in MA, etc
Vitamin C, selenium, and alpha-lipoic acid are also known to support glutathione activity
Medication prescriptions are based on medical recommendations from licensed healthcare providers
Age, comorbidities, and baseline tolerance all influence how patients respond to GLP-1 therapies