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Once reconstituted, the solution should be refrigerated and typically used within four weeks for best stability

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It represents the next generation beyond dual agonists like tirzepatide

For each disease, the total number of trials identified served as the denominator

The 2017 Neelakantan paper in Biochemistry characterised a fluorescent assay for direct real-time monitoring of NNMT enzymatic activity, providing the analytical foundation for inhibitor screening including 5-Amino-1MQ (PMID 28121423)