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Diarrhea For cagrilinitide and semagludide the risk of diarrhea was increasing for the lowest dosages at a faster rate, followed by a tendency to plateauing at highest dosages

With the help of proteomics, oxidative modifications to glycolytic enzymes, ATP synthase, -enolase, aconitase (enzyme containing iron-sulfur core), creatine kinase (maintains ATP levels in neurons), and other enzymes have been identified (Butterfield and Boyd-Kimball 2018)

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The problem has only become more complex with the skyrocketing use of glucagon-like peptide 1 class (GLP-1) drugs, such as Ozempic and Wegovy