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This is largely due to: Limited Long-Term Data: Most studies have only focused on short-term use of DSIP

The aggregation of these proteins impairs neuronal function by disrupting cellular balance and inducing toxicity

CO also suppressed the function of early growth response protein 1 (EGR-1), a crucial transcription factor in the inflammatory response initiated by macrophages [60]

10.1016/0192-0561(84)90069-9 50 KunwarR

A small pilot study designed to evaluate the safety of lipoic acid in 30 people with relapsing or progressive multiple sclerosis found that treatment with 1,200 to 2,400 mg/day of oral lipoic acid for two weeks was generally well tolerated (see Safety) (95)