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An elegant study (Gifford et al., 2016) showed that individuals with high CRF (VO 2 max, 59 mlkg 1 min 1 ) have high amounts of mitochondria (i.e., excess), and are far from saturating mitochondrial work capacity even in high-intensity PE

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The optimal therapeutic range for selenium is narrow: excess selenium intake can result in toxicity, while inadequate selenium affects thyroid function because of impaired synthesis and conversion of T4 into the active T312