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GLP-1 agonists work on leptin and ghrelin, impacting hunger and satiety signaling

J., Lopez, R., Cole, H

Serious adverse effects require clinical vigilance: Pancreatitis : Patients should be counseled to seek immediate medical attention for severe, persistent abdominal pain radiating to the back, with or without vomiting

Disruptions in circadian rhythm have also been widely reported in patients with bipolar disorder, and sleep deprivation is a known trigger, particularly of manic and hypomanic episodes [73,74,75,76]

That criticism is not the entire story