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These add substantial costs that research suppliers do not bear

The translation from mouse to human senolytic therapy has proven challenging for several reasons: species differences in senescent cell biology

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The phosphorylation-mimetic peptide S249/T252, derived from the retinoblastoma protein (RB), represents a novel advancement designed to emulate the phosphorylated state of RB at specific residues, S249 and T252, which are key targets of CDK4/6 kinases (Jin et al., 2019)