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Dopamine efflux by MPTP and hydroxyl radical generation

doi: 10.1038/ni.2985 14 von MeyennLBertschiNLSchlapbachC

Ongoing Used as a foundational antioxidant rather than a standalone fix

Over a 10-year period, the prevalence in younger individuals increased by 36% , from 4.5% to 7.8%, significantly outpacing the 11% rise in older individuals (ages 40 and above)

In addition to its role in the Trx system, NADPH provides reducing power to enzymes such as glutathione reductase and glutathione peroxidase (GPX), enabling the regeneration of antioxidant molecules (37,38)