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however, these investigations can be performed in secondary care (do not delay referral)

A 12-hour separation between isotretinoin and GTE capsule ingestion would still leave overlapping hepatic exposure windows

Nevertheless, given the strong binding activity of the fragment derivative 27 in the CPMG assay, a pure stock of 27 was synthesised and put forward for further characterisation using a quantitative LO-NMR assay to determine the dissociation constant