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Daily oral L-carnosine (500 mg, p.o., daily for 3 months) significantly ameliorated the pathophysiological triad of inflammation, oxidative stress, and apoptosis in patients receiving FOLFOX-6 regimen (OXA + 5FU + leucovorin), for instance, decreasing the molondialdehyde (MDA) level (51.8%), nuclear factor-B (NF-B) (27%), and TNF- (36.6%), while increasing Nrf-2 (38.7%) ( Therefore, antioxidant drugs, including small molecular drugs, Mn-based MRI contrast agents, and natural products could alleviate, to some extent, the symptoms of PIPN

This pathway operates independently of metabolic regulation but is particularly responsive to fluctuations in intracellular Ca 2+ levels and signaling

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Postinflammatory Hypopigmentation Postinflammatory Hypopigmentation Postinflammatory hypopigmentation is commonly observed during and after flares of seborrheic dermatitis , atopic dermatitis (Fig

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