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Also studied was the combined application of N G -nitro-L-arginine methylester (L-NAME) (5 mg/kg i.v.), a competitive inhibitor of endothelium nitric oxide (NO)-generation and the NO-precursor L-arginine (200 mg/kg i.v.) (D-arginine was ineffective)

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These effects of nicotinic acid are exerted by it binding to and activating the hydroxycarboxylic acid receptor 2 (HCA 2 ) which was originally identified as GPR109A

This copper peptide shows good results when tested on cells