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USA 96 , 13631368 (1999)

Statements Author contributions YS and XW wrote the manuscript

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Besides, berberine down-regulates the expression of acetylcholinesterase and inhibits acetylcholinesterase activity in Alzheimers disease model mice hippocampus which induced by heavy metals, in addition, berberine normalizes the production of inflammatory factors, such as tumor necrosis factor-alpha (TNF-), IL-6, IL-1 ( Studies demonstrated that berberine contributed to AMPK signaling pathway activation and participate in anti-neuroinflammation

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