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In contrast, the non-amyloidogenic pathway is characterized by more active -secretase-catalyzed cleavage (e.g., ADAM-10 and ADAM-17) of APP, releasing soluble APP from neuronal membranes into the interstitial space of the brain

Upon FINO2 treatment, cells exhibit a more extensive oxidized lipid profile, indicating that FINO2 carries out a Fenton reaction with Fe (II), creating alkoxyl radicals that lead to lipid peroxidation (55)

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