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10.1186/s12902-022-01036-0 104 RichardsP.PaisR.HabibA
Men over 40 typically see: Faster initial scale movement (58 lbs in weeks 14 versus 25 lbs for women) More linear weekly loss patterns Less hormonal water retention masking results Stronger early appetite suppression response Women over 40 typically see: Slower initial scale loss but more dramatic body composition change relative to scale weight Greater week-to-week scale fluctuation due to cycle and hormonal factors Faster muscle and waist response when protein intake is adequate More pronounced GI side effects at the same per-kilogram dose The most important difference is in the metrics that matter
In phase 3 clinical trials, participants using semaglutide (2.4 mg once weekly) showed 10-15% body weight reduction on average after 68 weeks
Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance
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